Generalizability of findings from neurobiological studies of individuals with first-episode psychosis: a cohort study
Using Swedish register data, we estimated the proportion of individuals with first-episode psychosis (FEP) who would be eligible to participate in a typical neurobiological study and found that only 39% met criteria. Eligible and ineligible individuals differed on sociodemographic variables and two-year outcome measures (inpatient admission, work disability). Our findings suggest that neurobiological studies may yield samples that are not fully representative of the wider FEP population, potentially limiting generalisability.
Authors
- Sophie Erhardt (ORCID: https://orcid.org/0000-0001-7359-5250)
- Pontus Josefsson
- Simon Červenka (ORCID: https://orcid.org/0000-0001-8103-6977)
- Maria Lee (ORCID: https://orcid.org/0000-0003-4080-4030)
- Alexis E. Cullen (ORCID: https://orcid.org/0000-0002-3178-3920)
- Carl M. Sellgren (ORCID: https://orcid.org/0000-0001-9103-2785)
- Ellenor Mittendorfer-Rutz
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- King's College London (GB)
- Karolinska Institutet (SE)
- Stockholm Health Care Services (SE)
Publication Details
- Journal
- Schizophrenia
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1038/s41537-026-00762-x
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet