Molecular and genetic landscape of amyotrophic lateral sclerosis in Latin America: a scoping review of pathogenic hypotheses and ancestral heterogeneity

: ALS research in Latin America remains limited, fragmented, and largely candidate-gene driven, with minimal integration of ancestry-informed approaches. The absence of large-scale genomic studies, despite existing regional sequencing capacity, highlights the need for coordinated multicenter initiatives to enable equitable implementation of precision medicine.

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Publication Details

Journal
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Published
2026-05-09
DOI
https://doi.org/10.1080/21678421.2026.2668070
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular and genetic landscape of amyotrophic lateral sclerosis in Latin America: a scoping review of pathogenic hypotheses and ancestral heterogeneity

Patricia Lillo, Jorge Briceño‐Moya, Sergio V. Flores, Ailin Pino-San Pedro
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Amyotrophic Lateral Sclerosis Research
article

Molecular and genetic landscape of amyotrophic lateral sclerosis in Latin America: a scoping review of pathogenic hypotheses and ancestral heterogeneity

Patricia Lillo, Jorge Briceño‐Moya, Sergio V. Flores, Ailin Pino-San Pedro
article en

Abstract

: ALS research in Latin America remains limited, fragmented, and largely candidate-gene driven, with minimal integration of ancestry-informed approaches. The absence of large-scale genomic studies, despite existing regional sequencing capacity, highlights the need for coordinated multicenter initiatives to enable equitable implementation of precision medicine.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Pontificia Universidad Católica de Chile (CL), Universidad Católica Silva Henríquez (CL), Hospital de São José (PT), Hospital Clínico de la Universidad de Chile (CL), University of Chile (CL), Arturo Prat University (CL)
Zero hunger
Openalex Percentile: Top 5%
Amyotrophic Lateral Sclerosis Research
DOISourceOpenAlex
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