RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages.
and disruption of the V-ATPase-ATG16L1 axis increased susceptibility in vivo. Thus, early endosome-to-phagosome trafficking can be selectively engaged to promote pathogen elimination by directing phagosomal maturation toward LAP.
Authors
- Patrícia Alves de Castro (ORCID: https://orcid.org/0000-0003-3045-6511)
- Fausto Bruno dos Reis Almeida (ORCID: https://orcid.org/0000-0002-3782-3698)
- Isabella Zaidan (ORCID: https://orcid.org/0000-0001-9434-8814)
- Emilio Boada-Romero (ORCID: https://orcid.org/0000-0003-2482-076X)
- Gustavo H. Goldman (ORCID: https://orcid.org/0000-0002-2986-350X)
- Marlon Fortes-Rocha (ORCID: https://orcid.org/0000-0002-2055-2000)
- Daniel L Alzamora-Terrel (ORCID: https://orcid.org/0000-0002-3793-3440)
- Larissa D. Cunha (ORCID: https://orcid.org/0000-0002-1290-0263)
- Camila Figueiredo Pinzan (ORCID: https://orcid.org/0000-0001-7635-2107)
- Edismauro Garcia Freitas Filho (ORCID: https://orcid.org/0000-0002-1910-1085)
- Carolina Bifano
- Renan Eugênio Araujo Piraine
- Caroline Patini de Rezende
- Thomas Wileman
- Oliver Florey
Institutions
- University of East Anglia (GB)
- Babraham Institute (GB)
- St. Jude Children's Research Hospital (US)
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1126/sciadv.adz0196
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00