PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.

-driven orthotopic pancreatic ductal adenocarcinoma model. Collectively, our data support selective PARP2 inhibition as a promising therapeutic strategy for pancreatic cancer by impairing genome integrity and boosting antitumor immune response, thereby opening potential avenues for combating this devastating disease.

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Publication Details

Journal
PubMed
Published
2026-05-08
DOI
https://doi.org/10.1126/sciadv.adu8849
Primary Topic
PARP inhibition in cancer therapy
Type
article
Field-Weighted Citation Impact
0.00
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article

PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.

Nura Lutfi, Noemí Manero‐Rupérez, Mireia Moreno, Gabriel A. Rabinovich et al.
PubMed
PARP inhibition in cancer therapy
article

PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.

Nura Lutfi, Noemí Manero‐Rupérez, Mireia Moreno, Gabriel A. Rabinovich, Pilar Navarro, Coral Ampurdanés, Ana Janic, Etna Abad, Carmen G. Lechuga, Neus Martínez‐Bosch, Carlos Martínez, Mar Iglesias, Núria Vázquez-Bellón, Carmen Guerra, José Yélamos, María Muñoz-Escribano, Cristina Ventura-Blanch, Meritxell Rovira, Bennett Nickell-Hernández
article en

Abstract

-driven orthotopic pancreatic ductal adenocarcinoma model. Collectively, our data support selective PARP2 inhibition as a promising therapeutic strategy for pancreatic cancer by impairing genome integrity and boosting antitumor immune response, thereby opening potential avenues for combating this devastating disease.

PubMedVol. 12(19)
Universitat Pompeu Fabra (ES), Universidad de Buenos Aires (AR), Institut d'Investigació Biomédica de Bellvitge (ES), Spanish National Cancer Research Centre (ES), Ajuntament de L’Hospitalet (ES), Institut d'Investigacions Biomèdiques de Barcelona (ES), Hospital Del Mar (ES), Instituto Murciano de Investigación Biosanitaria (ES), Centro de Investigación Biomédica en Red de Cáncer (ES), Institut Infància (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Fundación Ciencias Exactas y Naturales (AR), Experimental Medicine and Biology Institute (AR), Universitat de Barcelona (ES), Universidad de Murcia (ES)
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Openalex Percentile: Top 6%
PARP inhibition in cancer therapy
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