PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.
-driven orthotopic pancreatic ductal adenocarcinoma model. Collectively, our data support selective PARP2 inhibition as a promising therapeutic strategy for pancreatic cancer by impairing genome integrity and boosting antitumor immune response, thereby opening potential avenues for combating this devastating disease.
Authors
- Nura Lutfi
- Noemí Manero‐Rupérez
- Mireia Moreno
- Gabriel A. Rabinovich (ORCID: https://orcid.org/0000-0002-0947-8735)
- Pilar Navarro (ORCID: https://orcid.org/0000-0003-4314-4584)
- Coral Ampurdanés (ORCID: https://orcid.org/0000-0001-8607-5561)
- Ana Janic (ORCID: https://orcid.org/0000-0002-4200-2560)
- Etna Abad (ORCID: https://orcid.org/0000-0002-9431-5817)
- Carmen G. Lechuga
- Neus Martínez‐Bosch (ORCID: https://orcid.org/0000-0003-3596-0039)
- Carlos Martínez (ORCID: https://orcid.org/0000-0003-3307-1326)
- Mar Iglesias (ORCID: https://orcid.org/0000-0002-2274-4671)
- Núria Vázquez-Bellón
- Carmen Guerra (ORCID: https://orcid.org/0000-0002-3891-046X)
- José Yélamos
- María Muñoz-Escribano
- Cristina Ventura-Blanch
- Meritxell Rovira
- Bennett Nickell-Hernández
Institutions
- Universitat Pompeu Fabra (ES)
- Universidad de Buenos Aires (AR)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Spanish National Cancer Research Centre (ES)
- Ajuntament de L’Hospitalet (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Hospital Del Mar (ES)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Institut Infància (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Fundación Ciencias Exactas y Naturales (AR)
- Experimental Medicine and Biology Institute (AR)
- Universitat de Barcelona (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1126/sciadv.adu8849
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00