Advancements in Image-Based Artificial Intelligence in the Diagnosis and Treatment of Head and Neck Squamous Cell Carcinoma: A Narrative Review

Abstract: Head and neck squamous cell carcinoma (HNSCC) remains a significant global health challenge. Early detection, accurate diagnosis, and individualized treatment planning are essential for improving patient outcomes and enhancing quality of life. Artificial intelligence (AI), including radiomics and deep learning, has shown substantial potential in the early screening, accurate diagnosis, and treatment response prediction of HNSCC. In this review, we summarize the commonly used types of medical imaging and outline the basic workflows of radiomics and deep learning in medical image analysis. We then review the applications of AI in the clinical diagnosis and treatment of HNSCC across various aspects, including screening, diagnosis, staging and grading, pre-treatment evaluation, and prognostic prediction. We further discuss the convergence of AI with emerging imaging modalities, including hyperspectral imaging, optical coherence tomography, and Fourier transform infrared spectroscopy. Notably, most studies included in this review are retrospective and single-center in design, with limited external validation, underscoring the urgent need for prospective, multicenter research to facilitate clinical translation. Keywords: head and neck squamous cell carcinoma, medical imaging, artificial intelligence, deep learning, machine learning