<scp>RTD</scp> model and verification method of high‐throughput chaotic micromixer

Abstract A comprehensive understanding of residence time distribution (RTD) is crucial for the design and optimization of chaotic micromixers. However, due to inherent characteristics of small volumes and short residence times caused by high throughput, traditional RTD measurement technologies fail to meet these requirements, and no corresponding RTD mathematical models have been proposed. Here, an oscillating feedback micromixer (OFM) was selected as a representative high‐throughput chaotic micromixer. An RTD mathematical model for OFM was developed based on data obtained from computational fluid dynamics (CFD) simulations. Subsequently, a novel RTD measurement system with high temporal resolution, utilizing laser‐induced fluorescence (LIF) technology, was created to validate the reliability of the model. The results indicate that the developed RTD model accurately characterizes complex flow dynamics within OFM under high‐throughput conditions. Additionally, the LIF testing system significantly enhances measurement accuracy and fulfills the stringent requirements for measurement resolution associated with high throughput and short residence times.

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Publication Details

Journal
AIChE Journal
Published
2026-05-08
DOI
https://doi.org/10.1002/aic.70460
Primary Topic
Microfluidic and Capillary Electrophoresis Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

RTD model and verification method of high‐throughput chaotic micromixer

Cong Xu, Tingliang Xie, Wensheng Wang
AIChE Journal
Microfluidic and Capillary Electrophoresis Applications
article

RTD model and verification method of high‐throughput chaotic micromixer

Cong Xu, Tingliang Xie, Wensheng Wang
article en

Abstract

Abstract A comprehensive understanding of residence time distribution (RTD) is crucial for the design and optimization of chaotic micromixers. However, due to inherent characteristics of small volumes and short residence times caused by high throughput, traditional RTD measurement technologies fail to meet these requirements, and no corresponding RTD mathematical models have been proposed. Here, an oscillating feedback micromixer (OFM) was selected as a representative high‐throughput chaotic micromixer. An RTD mathematical model for OFM was developed based on data obtained from computational fluid dynamics (CFD) simulations. Subsequently, a novel RTD measurement system with high temporal resolution, utilizing laser‐induced fluorescence (LIF) technology, was created to validate the reliability of the model. The results indicate that the developed RTD model accurately characterizes complex flow dynamics within OFM under high‐throughput conditions. Additionally, the LIF testing system significantly enhances measurement accuracy and fulfills the stringent requirements for measurement resolution associated with high throughput and short residence times.

AIChE Journal
Ministry of Education (SA), Tsinghua University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 8%
Microfluidic and Capillary Electrophoresis Applications
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