Molecular characteristics, clonal relatedness and surgical outcomes of pulmonary mixed invasive mucinous and non-mucinous adenocarcinoma: a retrospective cohort study
T cells, was significantly higher in the NMA components compared to the IMA components. Postoperative follow-up revealed no significant difference in disease-free survival (DFS) or overall survival (OS) between NMA and mixed IMA/NMA cases; however, both groups showed significantly shorter DFS (P = 0.011) and OS (P = 0.027) compared to IMA cases. Together, this study provides a comprehensive characterization of the molecular profiles, clonal relatedness, tumor heterogeneity, and surgical outcomes of mixed IMA/NMA, which may inform diagnostic and therapeutic strategies for this rare LUAD subtype.
Authors
- Bowen Xue (ORCID: https://orcid.org/0000-0001-8673-706X)
- Nan Yao (ORCID: https://orcid.org/0000-0002-4081-1495)
- Wenhua Li (ORCID: https://orcid.org/0000-0002-9457-6662)
- Liming Xu
- Xinyi Shi (ORCID: https://orcid.org/0009-0005-3807-3322)
- Changbin Zhu
- Guiping Qin
- Yutao Liu
- Yang Wang
- Jianming Ying
- Lei Guo
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Dian Diagnostics (China) (CN)
- Tang Hospital (CN)
Publication Details
- Journal
- Molecular Biomedicine
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1186/s43556-026-00460-1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation