Alginate-based encapsulation of bioactive compounds from <i>Cannabis sativa</i> L. chemotype II: synthesis of microparticles, characterisation and <i>in vitro</i> release

) achieved high EE% (CBD 78.8 ± 0.9%; THC 46.5 ± 0.5% for CA-MPs) and high total cannabinoid content (up to 21.36% w/w). MPs exhibited monodisperse size distributions (PDI < 0.01). Stability tests demonstrated significant cannabinoid protection, although light exposure caused some degradation, especially for THC. Chitosan or pectin coatings increased particle size and modulated drug release, resulting in a three-phase pH-dependent profile with delayed release compared to uncoated MPs. Overall, alginate MPs with biopolymer coatings represent a promising oral delivery platform to enhance the stability and therapeutic efficacy of cannabis bioactives.