Integration of transcriptome and DNA methylation reveals the mechanism of cilia-related genes in recurrent miscarriage
T cells, and Th2 cells in RM, with SLC1A2 and ZDHHC20 expression positively correlated with these immune subsets. The ceRNA networks indicated that SLC1A2 and ZDHHC20 were modulated by 7 miRNAs and 19 lncRNAs, respectively. RT-qPCR results showed significant overexpression of SLC1A2, but not ZDHHC20, in RM chorionic tissue. Collectively, SLC1A2 represents a methylation-regulated CRG that links ciliary impairment, immune imbalance, and epigenetic modulation in RM, revealing a novel molecular axis and suggesting its diagnostic and therapeutic potential.
Authors
- Guangmei Xie
- Junning Jing (ORCID: https://orcid.org/0009-0005-1824-4729)
- Jing Li (ORCID: https://orcid.org/0009-0003-0221-1231)
- Dengcai Zhang
- Jingting Liu
- Liyuan Zhang
Institutions
- Gansu Provincial Maternal and Child Health Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1038/s41598-026-52154-x
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00