Synthesis, Characterization and Antihelminthic Activity of Some Pyrazole Derivative

Objective: The present study aimed to evaluate the antibacterial activity of different Pyrazole derivatives (4A–E) and screened against selected pathogenic microorganisms and to compare their efficacy with a standard antibiotic. Materials and Methods: The antibacterial activity of the developed formulations was assessed against Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus using the zone of inhibition method. The results were compared with the standard drug tetracycline to determine relative efficacy. Results: Among all formulations, 5B and 5C demonstrated the highest antibacterial activity, exhibiting significant zones of inhibition against all tested microorganisms. Strong activity was particularly observed against Pseudomonas aeruginosa and Staphylococcus aureus, indicating broad-spectrum effectiveness. Other formulations showed moderate to low activity, while some exhibited no inhibition against Klebsiella pneumoniae.