Physalin A Restores Redox and Mitochondrial Homeostasis to Protect against Diabetic Retinopathy
AIMS: mice. RESULTS: , and tight junction loss. In db/db mice treated systemically for 20 weeks, PA reduced Evans Blue leakage, increased retinal thickness, restored RPE tight junction proteins, and normalized mitochondrial architecture by transmission electron microscopy. PA rebalanced mitochondrial dynamics (dynamin 1-like, optic atrophy 1, fission 1, mitofusin 1, FUN14 domain containing 1), increased retinal mitochondrial DNA copy number, and partially stabilized glycemia and weight. CONCLUSION: 00, 000-000.
Authors
- Wei‐Cheng Jiang (ORCID: https://orcid.org/0000-0003-4432-8801)
- Wei‐Yong Lin (ORCID: https://orcid.org/0000-0002-8443-6180)
- Pei‐Ying Pai
- Yu‐Jung Lin (ORCID: https://orcid.org/0000-0001-5757-1021)
- Yow‐Wen Hsieh (ORCID: https://orcid.org/0000-0002-0523-3482)
- YU-SHENG HSIEH
- Dah-Yuu Lu
- Wen-Tsong Hsieh (ORCID: https://orcid.org/0000-0002-2330-8898)
- Yan-Ru Xiao
- Yueh-Hsiung Kuo
Institutions
- National Chung Cheng University (TW)
- China Medical University (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1177/15230864261442217
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00