Synthesis and Characterization of Mannich‐Derived 1,4‐Naphthoquinones From Lawsone: Photophysical Properties, Molecular Docking, BSA/DNA Interactions, and Antioxidant Activity
values for each compound. Evaluation of antioxidant properties demonstrated that all derivatives exhibited concentration-dependent radical scavenging activity within the range of 6.25-200 µg/mL. Notably, compound 8 exhibited superior antioxidant performance, displaying approximately twice the activity of standard antioxidants. Molecular docking studies were performed on compounds exhibiting the highest biological activity in vitro, and their binding properties and interaction profiles to target proteins were investigated.
Authors
- Seyit Ali Güngör (ORCID: https://orcid.org/0000-0002-3233-4529)
- Yavuz Deri̇n (ORCID: https://orcid.org/0000-0002-4935-2678)
- Ahmet Tutar (ORCID: https://orcid.org/0000-0001-5524-8001)
- Taoufik Rohand (ORCID: https://orcid.org/0000-0002-7370-9358)
- Büşra Albayrak Mısır (ORCID: https://orcid.org/0000-0003-0895-5699)
- Özge Güngör
- Raşit Fikret Yilmaz
Institutions
- Sakarya University (TR)
- Naval Academy (TR)
- Abdelmalek Essaâdi University (MA)
- Kahramanmaraş Sütçü İmam University (TR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1002/cbdv.202503544
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00