Novel 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Amidines as Phytopathogen Fungicides: Design, Synthesis, Activity, and SAR
achieved 95-100% control efficacy at 25 mg/L, comparable to propiconazole. SAR studies revealed that activity was governed by the oxadiazole position and amidine substituents. Molecular docking and DFT calculations elucidated their potential binding mode to HDAC isoforms. This work identifies these compounds as promising lead structures for novel HDAC-targeting fungicides.
Authors
- Cheng‐Xia Tan (ORCID: https://orcid.org/0000-0003-1000-8578)
- Zhen-yu Lian
- Liangkun Zhong (ORCID: https://orcid.org/0000-0003-1240-0709)
- Jian‐Quan Weng (ORCID: https://orcid.org/0000-0001-5513-6421)
- Fu-Xiang Han
- Tian-Ming Xu
- Xu-Feng Liu
- Xing-Hai Liu (ORCID: https://orcid.org/0000-0003-1464-1426)
Institutions
- Ningbo University of Technology (CN)
- Zhejiang Research Institute of Chemical Industry (CN)
- Shanghai Pesticide Research Institute (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1021/acs.jafc.5c14806
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province