Endogenous Shear‐Responsive Chemiluminescence Theranostics for Self‐Illuminating Thrombosis Imaging and Piezo‐Photodynamic Therapy

for photodynamic therapy (PDT), creating a piezocatalysis-chemiluminescence-energy transfer cascade. In a rat model of carotid artery thrombosis, RGD-targeted NRs achieve four-fold higher luminescence for deep-tissue imaging without external excitation, and combined piezocatalysis, PDT, and RGD-mediated targeting realize 97.7% thrombolysis efficiency. This work pioneers an innovative theranostic approach driven by endogenous shear force, enabling clot site-specific and stenosis degree-adaptive thrombosis imaging and thrombus dissolution.