Cuevaenes F–H, Including Two Rare Chlorinated Cuevaenes From the Marine‐Derived <i>Streptomyces malaysiensis</i> HNM0561
) to afford the corresponding methyl esters (1a-6a). All isolated and derivatized compounds (1-7 and 1a-6a) were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV2 microglial cells. Among them, compounds 3 and 4a exhibited significant inhibitory activity, reducing NO production by 54% and 47% at a concentration of 20 µM, respectively.
Authors
- Shuang-Qing Zhou
- Zhiwei Hong (ORCID: https://orcid.org/0000-0002-7006-0397)
- Yan-Fang Luo
- Xiao‐Long Huang
- Shen‐Hao Luo
- Yan‐Ping Huang
- Zhong‐Ping Jiang (ORCID: https://orcid.org/0009-0008-8372-6670)
Institutions
- Hainan Normal University (CN)
- Guilin Medical University (CN)
- Hainan University (CN)
- JiangSu Armed Police General Hospital (CN)
- Chinese People's Armed Police General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1002/cbdv.71279
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China