Btg2 inhibits Fmo1 UFMylation thus exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury
mice. Mechanistically, Btg2 suppresses UFMylation of flavin-containing monooxygenase 1 (Fmo1), a key taurine synthesis enzyme, promoting its K48-linked ubiquitination and degradation. Virus-mediated Fmo1 overexpression inhibits ferroptosis, apoptosis, and HIRI significantly both in vivo and in vitro. Virtual screening of natural compounds indicates that Daturataturin A (DTA) inhibits Btg2, thereby attenuating ferroptosis and HIRI. These results suggest that Btg2 may constitute a promising therapeutic target for HIRI.
Authors
- Dengliang Lei
- Kezhen Zong (ORCID: https://orcid.org/0000-0003-2233-5488)
- Liqing Jiang (ORCID: https://orcid.org/0000-0001-6360-0052)
- Yunhai Luo (ORCID: https://orcid.org/0000-0001-6948-2042)
- Zuotian Huang (ORCID: https://orcid.org/0000-0003-4688-5820)
- Zhongjun Wu (ORCID: https://orcid.org/0000-0002-1627-0633)
- Yihua Wang
- Qiuying Li
- Yulin Ou
- Shanshan Li (ORCID: https://orcid.org/0000-0002-7041-5960)
- Weifeng Huang
- Huarong Yu (ORCID: https://orcid.org/0000-0002-0916-3039)
- Dadi Peng
- Jiayin Yang (ORCID: https://orcid.org/0009-0002-7221-4932)
Institutions
- Guiyang Medical University (CN)
- Army Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Cancer Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1038/s41467-026-72455-z
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00