sc-ChromAging: A Single-Cell Chromatin Accessibility-based Clock Decodes Cell-Type-Specific Epigenetic Aging Trajectories
sc-ChromAging, a chromatin accessibility-based aging clock, was developed using single-cell ATAC-seq from 401 Chinese individuals. It identified CD4⁺ naive T cells as the most accurate predictors of age. This clock linked immune aging with pathways in inflammation, infection, and tumor susceptibility, and connecting chromatin changes to plasma metabolites like triacylglycerols.
Authors
- Junyu Shi (ORCID: https://orcid.org/0000-0001-8803-3621)
- Xindi Wei (ORCID: https://orcid.org/0000-0002-0313-339X)
- Hongchang Lai
- Youcheng Dong
Institutions
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- npj Aging
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1038/s41514-026-00398-2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China