<i>MiR-155</i>-driven loss of ICOSL and SOCS1 in EBV+ gastric cancers renders abundant cytotoxic T cells ineffective, enabling immune evasion.

, along with ICOSL status determines whether tumors attract T cells and whether those T cells can effectively eradicate cancer cells.

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Publication Details

Journal
PubMed
Published
2026-05-12
DOI
https://doi.org/10.1073/pnas.2536375123
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

MiR-155-driven loss of ICOSL and SOCS1 in EBV+ gastric cancers renders abundant cytotoxic T cells ineffective, enabling immune evasion.

Hajime Otsu, Gerard J. Nuovo, Koshi Mimori, Esmerina Tili et al.
PubMed
MicroRNA in disease regulation
article

MiR-155-driven loss of ICOSL and SOCS1 in EBV+ gastric cancers renders abundant cytotoxic T cells ineffective, enabling immune evasion.

Hajime Otsu, Gerard J. Nuovo, Koshi Mimori, Esmerina Tili, Carlo M Croce
article en

Abstract

, along with ICOSL status determines whether tumors attract T cells and whether those T cells can effectively eradicate cancer cells.

PubMedVol. 123(19)
The Ohio State University Wexner Medical Center (US), CS Diagnostics (DE), Kyushu University Beppu Hospital (JP)
Zero hunger
Openalex Percentile: Top 7%
MicroRNA in disease regulation
DOISourceOpenAlex
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