Abdominal giant cell tumor of soft tissue: A case report with diagnostic pointers

Giant cell tumor of soft tissue (GCTST) is a rare primary neoplasm of soft tissues, usually occurring in the upper and lower extremities. It can be superficial or deep. The documentation of other rare sites is limited to case reports of the trunk, head, neck, and abdominal wall. The present case describes GCTST in the abdominal wall of a 36-year-old female. The patient presented with a non-tender abdominal mass in the right lumbar region. Ultrasonography revealed a hypoechoic lesion measuring 28 × 27 mm. An excision biopsy was performed. Histopathological examination showed a tumor histologically similar to a giant cell tumor with low mitosis. A diagnosis of GCTST was made. The patient was advised to undergo clinical and radiological follow-up to monitor for recurrence. The patient is disease-free after a 6-month follow-up. GCTST is histologically similar to giant cell tumors of bone. However, it lacks H3F3A gene mutations. It is a tumor with low malignant potential. In view of the limited literature available on the entity, a long-term follow-up is recommended to rule out recurrence.