Natural noncoding <i>pumilio</i> variants retune value-coding interneurons to bias <i>Drosophila</i> oviposition decisions.
in these neurons converts the laboratory flies' physiology and behavior to the African phenotype. These findings offer a genome-to-circuit-to-behavior framework, revealing how subtle regulatory polymorphisms fine-tune circuit properties to diversify environment-appropriate decision biases in nature.
Authors
- Dorsa Motevalli (ORCID: https://orcid.org/0000-0002-5083-4631)
- Runling Yang (ORCID: https://orcid.org/0000-0003-2117-3595)
- Emmanuel Medrano (ORCID: https://orcid.org/0000-0002-2773-3496)
- Toshihide Hige (ORCID: https://orcid.org/0000-0003-0715-892X)
- William I. Silander (ORCID: https://orcid.org/0000-0002-0007-3192)
- Sydney Fogleman
- Robert Alfredson
- Yang Chen
- Ulrich Stern
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1126/sciadv.aed1338
- Primary Topic
- Neurobiology and Insect Physiology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00