Angiotensin <scp>II</scp> Promotes the Phenotypic Transition of c‐Kit <sup>+</sup> Cardiac Interstitial Cells to Myofibroblasts Through Collagen Receptor Discoidin Domain Receptor 2

CICs in morphology. Collectively, these results suggest that c-Kit expression in myofibroblasts may potentially mitigate the adverse effects of cardiac fibrosis and promote favorable remodeling in the long term.

Authors

Divya M. Sivaraman
Neethu Mohan (ORCID: https://orcid.org/0000-0003-4595-2331)
Indraja Devidasan
Sruthi Radhakrishnan
Vivek V. Pillai
Sarayu Gopal
Geethu S. Nair

Institutions

Sree Chitra Thirunal Institute for Medical Sciences and Technology (IN)

Publication Details

Journal: BioFactors
Published: 2026-05-01
DOI: https://doi.org/10.1002/biof.70108
Primary Topic: Cell Adhesion Molecules Research
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Indian Council of Medical Research

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article

Angiotensin II Promotes the Phenotypic Transition of c‐Kit ⁺ Cardiac Interstitial Cells to Myofibroblasts Through Collagen Receptor Discoidin Domain Receptor 2

Divya M. Sivaraman, Neethu Mohan, Indraja Devidasan, Sruthi Radhakrishnan et al.

May 1, 2026

BioFactors

Cell Adhesion Molecules Research

article

Angiotensin II Promotes the Phenotypic Transition of c‐Kit ⁺ Cardiac Interstitial Cells to Myofibroblasts Through Collagen Receptor Discoidin Domain Receptor 2

Divya M. Sivaraman, Neethu Mohan, Indraja Devidasan, Sruthi Radhakrishnan, Vivek V. Pillai, Sarayu Gopal, Geethu S. Nair

May 1, 2026article en

Abstract

CICs in morphology. Collectively, these results suggest that c-Kit expression in myofibroblasts may potentially mitigate the adverse effects of cardiac fibrosis and promote favorable remodeling in the long term.

BioFactorsVol. 52(3)

Sree Chitra Thirunal Institute for Medical Sciences and Technology (IN)

Indian Council of Medical Research

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Openalex Percentile: Top 6%

Cell Adhesion Molecules Research

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