Antigen spreading mediates heterogeneous solid tumor eradication by DNA demethylating agent-programmed CAR T cells.
T cells, enhancing their antigen-spreading capacity and aiding in the clearance of abscopal antigen-negative tumors. These findings reveal the robust antigen-spreading capability of dCAR T cells, underscoring their clinical potential in addressing solid tumors with inherent antigen heterogeneity.
Authors
- Yipeng Zhang (ORCID: https://orcid.org/0000-0003-2411-5390)
- Jianshu Wei (ORCID: https://orcid.org/0000-0002-9778-7131)
- Yuting Lu
- Chuan Tong
- Fengxia Shi
- Yao Wang
- Chunmeng Wang
- Fuxin Han
- Zhiqiang Wu
- Weidong Han
- Jinhong Shi
- Yelei Guo
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1126/sciadv.adz4088
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00