Single Atom‐Enhanced Piezo‐Flexoelectric Field Coupling Catalytic Sterilization With Self‐Powered Directional Stimulation for Wound Healing

ABSTRACT Thermal burns present significant challenges in infection control and tissue repair, with existing enzymatic and electrical therapies facing issues of unsustainability, invasiveness, and catalytic limitations. Herein, we propose innovative mechanical stretching‐powered ε‐polylysine hydrogels with conjugated Pt single‐atom‐anchored MXenes (Pt‐M). Pt anchoring on self‐reducing Ti‐vacancies of Ti 3 C 2 T x amplifies strain gradient and lattice distortion, enhancing the piezo‐flexoelectric (PFE) response of Pt‐M. Pt single‐atom enzyme (SAzyme)‐catalyzed generation of ∙OH initiates in situ crosslinking of methacrylated ε‐polylysine‐grafted Pt‐M to form wound‐adaptive Pt‐M@PL hydrogels, maximizing wound fitting and skin motion‐derived mechanical force to activate the PFE response. PFE field of Pt‐M dynamically switches the spin state and polarizes charge distribution of Pt SAzymes, altering the rate‐determining step and accelerating O─O bond cleavage and H + adsorption to generate ·OH for antibacterial effect. The high PFE field coupling endogenous ions breaks charge balance within the electrical double layers (EDL) on polylysine molecule chains. The formed directional electric field at the biological interface promotes free diffusion of intracellular ions to conserve adenosine 5'‐triphosphate and macrophage phenotype transition, remodeling the wound microenvironment to enhance tissue regeneration. Thus, these injectable hydrogels generate a self‐powered PFE field to enhance SAzyme catalysis for sterilization and EDL‐directed electric stimulation for the subsequent wound healing.