Enantio- and regioselective nickel/photoredox-catalyzed cross-electrophile coupling of benzylic aziridines with alkynyl bromides.
-amino acids. Mechanistic studies were indicative of the aziridine being activated through a regioselective nucleophilic halide ring opening and subsequent enantioselective XEC of the generated β-amino benzyl halides with alkynyl bromides.
Authors
- Zhuangzhi Shi (ORCID: https://orcid.org/0000-0003-4571-4413)
- Hongyan Lan
- Prof. Dr. Lutz Ackermann
- Zhao-Dong Xu
- Dingyi Wang
Institutions
- University of Göttingen (DE)
- Southeast University (CN)
- Nanjing University (CN)
- Northeastern University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1126/sciadv.aef4526
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00