A BcfA-containing intranasal vaccine generated TH17 immunity and reduced B. bronchiseptica colonization and disease in mice

17 polarized systemic and tissue-resident CD4 + T cells and systemic and mucosal IgG and IgA antibodies. Immunized mice were protected against weight loss, bronchoconstriction and cough and displayed reduced lung inflammation. Following challenge, Bb was cleared from the lungs and reduced in the nose of immunized mice. This subunit vaccine has the potential to provide sustained protection against Bb infection and disease in companion and farm animals.