Beta-cardiotoxin, a funny current inhibitor, and its effect on ion channels involved in heart rate regulation and on calcium transient profile in mouse sinoatrial node cells
INTRODUCTION: Beta-cardiotoxin (β-CTX) from the king cobra venom possesses a negative chronotropic effect on rat hearts. However, the mechanism of β-CTX-induced bradycardia remains unknown. Therefore, this study aimed to elucidate its role on ion channels and intracellular calcium transients involved in heart rate regulation in mouse sinoatrial node (SAN) cells. MATERIALS AND METHODS: ), and intracellular calcium transient profiles in isolated mouse SAN cells. RESULTS: at the same concentration. Additionally, β-CTX significantly reduced the frequency of calcium transients in SAN cells by 32%. DISCUSSION AND CONCLUSIONS: activities. These characteristics of β-CTX would support the further development of a novel heart rate-reducing agent for the treatment of tachyarrhythmia or diastolic dysfunction.
Authors
- Isabelle Bidaud (ORCID: https://orcid.org/0000-0002-1812-1447)
- Sarawut Kumphune (ORCID: https://orcid.org/0000-0003-4940-7103)
- Chirutchaya Pinidmontree (ORCID: https://orcid.org/0000-0001-9783-800X)
- Kittipong Tachampa (ORCID: https://orcid.org/0000-0002-2011-3542)
- Cho Yeow Koh (ORCID: https://orcid.org/0000-0003-0002-4603)
- R. Manjunatha Kini (ORCID: https://orcid.org/0000-0002-6100-3251)
- M Mangoni
- Pietro Mesirca (ORCID: https://orcid.org/0000-0002-9538-3096)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Chulalongkorn University (TH)
- National University of Singapore (SG)
- Institut de Génomique Fonctionnelle (FR)
- Chiang Mai University (TH)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1016/j.biopha.2026.119386
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Graduate School, Chulalongkorn University
- Agence Nationale de la Recherche
- Fondation Leducq
- Chulalongkorn University
- National Research Council of Thailand
- Thailand Science Research and Innovation