Chinese guidelines for HER2-targeted therapy in gastric and gastroesophageal junction adenocarcinoma (2025 Edition)

Gastric and gastroesophageal junction adenocarcinoma (GC/GEJC) poses a substantial clinical burden in China. This updated guideline introduces a refined human epidermal growth factor receptor 2 (HER2) classification system (high, intermediate, low, absent) to redefine patient stratification for targeted therapy. It integrates cutting-edge evidence on standardized detection-including immunohistochemistry, in situ hybridization, and liquid biopsy-to overcome spatial-temporal heterogeneity. Recent progress in the use of HER2-targeted agents, including monoclonal antibodies, antibody-drug conjugates, tyrosine kinase inhibitors, and bispecific antibodies, is systematically reviewed and presented to inform evidence-based clinical practice. These updates aim to optimize personalized HER2-targeted therapy and improve outcomes in GC/GEJC patients.

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Publication Details

Journal
Journal of Hematology & Oncology
Published
2026-05-08
DOI
https://doi.org/10.1186/s13045-026-01804-8
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

Chinese guidelines for HER2-targeted therapy in gastric and gastroesophageal junction adenocarcinoma (2025 Edition)

姚晓虹, Ruihua Xu, Miaozhen Qiu, Dongmei Lin et al.
Journal of Hematology & Oncology
Gastric Cancer Management and Outcomes
article

Chinese guidelines for HER2-targeted therapy in gastric and gastroesophageal junction adenocarcinoma (2025 Edition)

姚晓虹, Ruihua Xu, Miaozhen Qiu, Dongmei Lin, Xiaotian Zhang, Muyan Cai, Hong Bu, Xiujuan Qu, Jin Li, Jie’er Ying, Chang Wang, Zhi Peng, Yakun Wang, Tianshu Liu, Jianming Ying, Wenlong Guan, Fenghua Wang, Weiqi Sheng, Xiangshan Fan, Yueping Liu, Ziyu Li, Lin Shen, Tong Xie
article en

Abstract

Gastric and gastroesophageal junction adenocarcinoma (GC/GEJC) poses a substantial clinical burden in China. This updated guideline introduces a refined human epidermal growth factor receptor 2 (HER2) classification system (high, intermediate, low, absent) to redefine patient stratification for targeted therapy. It integrates cutting-edge evidence on standardized detection-including immunohistochemistry, in situ hybridization, and liquid biopsy-to overcome spatial-temporal heterogeneity. Recent progress in the use of HER2-targeted agents, including monoclonal antibodies, antibody-drug conjugates, tyrosine kinase inhibitors, and bispecific antibodies, is systematically reviewed and presented to inform evidence-based clinical practice. These updates aim to optimize personalized HER2-targeted therapy and improve outcomes in GC/GEJC patients.

Journal of Hematology & Oncology
Hebei Medical University (CN), Shanghai Medical College of Fudan University (CN), Army Medical University (CN), Sun Yat-sen University (CN), Anhui Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Sichuan University (CN), Fudan University (CN), National Cancer Center (US), Fudan University Shanghai Cancer Center (CN), Peking University Cancer Hospital (CN), Zhejiang Cancer Hospital (CN), Fourth Hospital of Hebei Medical University (CN), Second Affiliated Hospital of Inner Mongolia Medical University (CN), Zhongshan Hospital (CN), Shanghai East Hospital (CN), Southwest Hospital (CN), First Affiliated Hospital of Anhui Medical University (CN), First Hospital of China Medical University (CN), Sun Yat-sen University Cancer Center (CN), Inner Mongolia Medical University (CN), China Medical University (CN)
Beijing Xisike Clinical Oncology Research Foundation
Good health and well-being, Zero hunger
Openalex Percentile: Top 6%
Gastric Cancer Management and Outcomes
DOIOpen Access PDFOpenAlex
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