Genome Mining-Guided Discovery of the Glycosylated Griseorhodin Congener Ruskamycin

, predicted to enable the biosynthesis of a glycosylated griseorhodin variant. Following the successful cultivation of the strain, the production of a previously uncharacterized griseorhodin, named ruskamycin, was confirmed that featured a distinctive digitoxose-substituted epoxy-spiroketal pharmacophore and exhibited antibacterial activity against Gram-positive strains.