Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca <sup>2+</sup> ‐Dependent Endoplasmic Reticulum Stress in Distal Tubules
homeostasis and suppressing ER stress in distal TECs. Furthermore, supplementation with a cell-permeable Cav-1 scaffolding domain peptide (CSP) or activation of SERCA2 with a small-molecule agonist CDN1163 alleviates IRI- and LPS-induced AKI, while distal TEC-specific SERCA2 knockdown abrogates CSP's therapeutic effect. Together, these findings reveal a novel Cav-1-mediated pathway and highlight its potential as a therapeutic target for AKI.
Authors
- Yiwei Xiong (ORCID: https://orcid.org/0000-0002-6205-4691)
- Lijian Tao
- J Cheng
- Zhangzhe Peng (ORCID: https://orcid.org/0009-0002-0804-3921)
- Yanyun Xie (ORCID: https://orcid.org/0000-0002-2985-6414)
- Qiongjing Yuan
- Qi Li (ORCID: https://orcid.org/0000-0001-8776-8730)
- Jie Meng (ORCID: https://orcid.org/0000-0002-4402-1589)
- Sijue Zou
- Li S
- H U I Yang
- R H Lu
- Xin He
- Ling Huang
- Jiaxi Pu
- Shao Liu (ORCID: https://orcid.org/0000-0002-0576-8698)
- Xin Lv
- Hao Huang (ORCID: https://orcid.org/0000-0001-9051-4483)
- Yan Zhang
- Zhenghao Deng
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Changsha University (CN)
- Hunan Provincial People's Hospital (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1002/advs.75449
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province