Synergistic Effects of a Methyl Pyropheophorbide–Cystamine–Ferrocenecarboxylic Acid Ternary Conjugate on Targeted Regulation of Tumor Hypoxia and Immune Suppression for Remodeling the Tumor Immune Microenvironment
experiments demonstrate that, when combined with immune checkpoint blockade (ICB) therapy, HCFCMP not only significantly inhibits primary tumor growth but also effectively suppresses distant tumor progression. This substantially improves the immunotherapeutic response rate and provides a promising strategy for addressing tumor metastasis and recurrence.
Authors
- Minghao Sun (ORCID: https://orcid.org/0000-0002-8317-5847)
- Yibo Huo
- Siran Jin
- Xu Zhu (ORCID: https://orcid.org/0009-0009-5731-4194)
- Xiaodan Wu
- Yingxue Jin (ORCID: https://orcid.org/0000-0001-7976-2785)
- Hui Zhang
- Qingyun Li
- Zheng Cheng
- Yuanjin Sun
Institutions
- Harbin Normal University (CN)
- Yonsei University (KR)
- Mudanjiang Medical University (CN)
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.bioconjchem.6c00191
- Primary Topic
- Ferrocene Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Heilongjiang Province
- Heilongjiang Provincial Science and Technology Department