MicroRNA profiles in colostrum and transition milk of non-dairy goats fed with or without resveratrol

MicroRNAs are non-coding RNAs that regulate gene expression at the post-transcriptional level. To aid research on support the study of microRNAs in goat milk, we provide a dataset describing the microRNA profiles of small extracellular vesicles from colostrum and transition milk of dairy goats fed either a standard diet or a diet supplemented with resveratrol. In this study, we analyzed the microRNA profiles in small extracellular vesicles (sEVs) from colostrum and transition milk of dairy goats supplemented with or without resveratrol. A total of 30 milk samples were analyzed and 406 known microRNAs were identified, with let-7c-5p (10.48% ± 0.54%) being the most abundant, followed by let-7a-5p (9.18% ± 0.47%) and let-7f-5p (8.19% ± 0.43%). The microRNA profiles were clustered into two groups (0 d and 7 d) irrespective of resveratrol supplementation. This resource enables comparative studies of microRNA composition in goat colostrum and transition milk, facilitates research into the effects of diet on milk microRNAs, and supports studies on the transmission and function of microRNAs in neonatal development.