Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling
signaling point to PITPα/β and PI4KIIα as potential therapeutic targets in this pathway for mutant p53 driven cancers.
Authors
- Noah D. Carrillo (ORCID: https://orcid.org/0000-0002-1914-1095)
- Tianmu Wen (ORCID: https://orcid.org/0009-0002-2495-5488)
- Dhruv Brahmbhatt
- Richard A. Anderson (ORCID: https://orcid.org/0000-0002-7495-518X)
- Colin Sterling
- Poorwa Awasthi (ORCID: https://orcid.org/0000-0001-9594-5661)
- Vincent L. Cryns
- Xue Yang
- Mo Chen (ORCID: https://orcid.org/0000-0002-3274-5889)
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Carbone Cancer Center (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2026.113123
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Breast Cancer Research Foundation
- Guangdong Medical Research Foundation
- Shenzhen Fundamental Research Program
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Environmental Health Sciences