Enhanced Antibiotic Dissipation in Swine Wastewater Facilitated by Heavy Metals through a Transcriptionally Upregulated Microalgal Metallohydrolase
jointly stabilize the active conformation of MHO, enabling metal-dependent degradation of enrofloxacin and sulfadiazine into less toxic derivatives. The enzyme and the evolved strain exhibited broad pH and temperature tolerance, along with broad-spectrum degradation ability toward multiple fluoroquinolones and sulfonamides. This study unveils a previously unrecognized microalgal detoxification mechanism and demonstrates adaptive evolution as a powerful tool for engineering robust strains for complex wastewater bioremediation.
Authors
- Peizeng Yang (ORCID: https://orcid.org/0000-0002-2647-6619)
- Xiang Wang (ORCID: https://orcid.org/0000-0003-4743-4706)
- Si-Fen Liu
- Jin‐Hua Mou (ORCID: https://orcid.org/0000-0001-9147-0187)
- Yucheng Yang (ORCID: https://orcid.org/0000-0001-8817-1741)
- Carol Sze Ki Lin (ORCID: https://orcid.org/0000-0002-8493-4307)
- Wei‐Dong Yang (ORCID: https://orcid.org/0000-0002-3002-0972)
- Yi-Fan Zhan
- Hong-Ye Li
- Bin Lin
Institutions
- Nanjing Agricultural University (CN)
- City University of Hong Kong (HK)
- Xiamen University (CN)
- Guangdong Polytechnic of Science and Technology (CN)
- Computational Physics (United States) (US)
Publication Details
- Journal
- Environmental Science & Technology
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.est.5c15763
- Primary Topic
- Pharmaceutical and Antibiotic Environmental Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province