Outside Front Cover: Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction
Efficient delivery of proteins into cells remains a major challenge in biomedical and biochemical research. In Research Article e24419, Christian P. R. Hackenberger and co-workers introduce polyfluoroalkyl-tagged cell-penetrating peptides (CPPs) that can enhance protein delivery via prolonged membrane retention. The cover illustrates that polyfluoroalkyl-tagged CPPs can interact with lipid bilayers as monomers and partially insert into the outer membrane leaflet, a key insight revealed through biophysical experiments and molecular dynamics simulations. Image credit to Barth van Rossum (FMP).
Authors
- Joachim Heberle (ORCID: https://orcid.org/0000-0001-6321-2615)
- Jan Vincent V. Arafiles (ORCID: https://orcid.org/0000-0002-7733-7563)
- Hana Zupan (ORCID: https://orcid.org/0000-0002-5501-3883)
- Martin Lehmann (ORCID: https://orcid.org/0000-0002-8370-6353)
- Ferhat Mutlu (ORCID: https://orcid.org/0000-0003-2234-021X)
- Bettina G. Keller (ORCID: https://orcid.org/0000-0002-7051-0888)
- Palina Dubatouka
- Sarah Hansen (ORCID: https://orcid.org/0000-0002-7639-2886)
- Rubén Cruz
- Christian P. R. Hackenberger
- Kenichi Ataka
Institutions
- Humboldt-Universität zu Berlin (DE)
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1002/anie.2026-m0405080500
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00