Resistant to Ablation, Responsive to Hydroquinidine: Precision Medicine Guides Recovery in <scp>MEPPC</scp> Syndrome Cardiomyopathy
p.Arg814Trp variant. Genetic diagnosis enabled precision pharmacotherapy with hydroquinidine, which suppressed multifocal Purkinje-origin ectopy resistant to catheter ablation and led to marked improvement in left ventricular function.
Authors
- Hariharan Raju (ORCID: https://orcid.org/0000-0003-0000-7520)
- Malcolm Anastasius
- Jonathan L. Ciofani
Institutions
- The University of Sydney (AU)
- Royal North Shore Hospital (AU)
- Concord Repatriation General Hospital (AU)
- Imperial College London (GB)
- Macquarie University (AU)
Publication Details
- Journal
- Journal of Arrhythmia
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1002/joa3.70318
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00