Toward a Small Molecule Therapy for Angelman Syndrome: Structure–Activity Relationship Studies of 3-Aminopyrazole Phenylacetamides as Paternal <i>Ube3a</i> Unsilencers

Authors

Jon L. Collins (ORCID: https://orcid.org/0009-0007-8086-1802)
K. Li (ORCID: https://orcid.org/0000-0002-9275-4381)
Allison Zhang (ORCID: https://orcid.org/0000-0002-8898-3595)
Hanna Vihma (ORCID: https://orcid.org/0000-0002-6128-636X)
Hsueh-Cheng Huang
Anna Welton-Arndt (ORCID: https://orcid.org/0009-0007-5629-8589)
Hannah C. Nourie
Siyuan Liang
Jonathan Super
Jeffrey Aubé (ORCID: https://orcid.org/0000-0003-1049-5767)
Benjamin D. Philpot (ORCID: https://orcid.org/0000-0003-2746-9143)
Ashley E. Trojniak

Institutions

University of North Carolina at Chapel Hill (US)
Discovery Centre (CA)
New York State Office for People With Developmental Disabilities (US)
Deerfield (United States) (US)
Institute of Medicinal Plant Development (CN)
Chancellor University (US)

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-05-08
DOI: https://doi.org/10.1021/acs.jmedchem.6c00168
Primary Topic: Genetic Syndromes and Imprinting
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Institutes of Health
National Institute of Neurological Disorders and Stroke
Division of Chemistry

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article

Toward a Small Molecule Therapy for Angelman Syndrome: Structure–Activity Relationship Studies of 3-Aminopyrazole Phenylacetamides as Paternal Ube3a Unsilencers

Jon L. Collins, K. Li, Allison Zhang, Hanna Vihma et al.

May 8, 2026

Journal of Medicinal Chemistry

Genetic Syndromes and Imprinting

article

Toward a Small Molecule Therapy for Angelman Syndrome: Structure–Activity Relationship Studies of 3-Aminopyrazole Phenylacetamides as Paternal Ube3a Unsilencers

Jon L. Collins, K. Li, Allison Zhang, Hanna Vihma, Hsueh-Cheng Huang, Anna Welton-Arndt, Hannah C. Nourie, Siyuan Liang, Jonathan Super, Jeffrey Aubé, Benjamin D. Philpot, Ashley E. Trojniak

May 8, 2026article en

Abstract

No abstract available for this paper.

Journal of Medicinal Chemistry

University of North Carolina at Chapel Hill (US), Discovery Centre (CA), New York State Office for People With Developmental Disabilities (US), Deerfield (United States) (US), Institute of Medicinal Plant Development (CN), Chancellor University (US)

National Institutes of Health, National Institute of Neurological Disorders and Stroke, Division of Chemistry

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Openalex Percentile: Top 6%

Genetic Syndromes and Imprinting

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Toward a Small Molecule Therapy for Angelman Syndrome: Structure–Activity Relationship Studies of 3-Aminopyrazole Phenylacetamides as Paternal <i>Ube3a</i> Unsilencers — Jon L. Collins, K. Li, et al. · Journal of Medicinal Chemistry (2026) | TGRS Research Map | TGRS