Comprehensive review of the cerebral aqueduct: anatomy, embryology, imaging, genetics, molecular, and pathology
mutations and broader molecular pathways implicated in congenital hydrocephalus. Surgical strategies, including endoscopic third ventriculostomy, aqueductoplasty, and transaqueductal stenting, are critically appraised in terms of efficacy, complication profiles, and long-term outcomes. Overall, this review underscores the CA as a nexus of neurodevelopment, neuropathology, and neurosurgical innovation, and identifies gaps in knowledge that merit future investigation.
Authors
- Nikola Vučinić (ORCID: https://orcid.org/0000-0003-4419-6255)
- Carmine Antonio Donofrio (ORCID: https://orcid.org/0000-0002-9123-8158)
- Filippo Badaloni (ORCID: https://orcid.org/0000-0002-0041-0945)
- Aaron S. Dumont (ORCID: https://orcid.org/0000-0002-8077-8992)
- Noritaka Komune (ORCID: https://orcid.org/0000-0002-9521-9878)
- Antonio Fioravanti (ORCID: https://orcid.org/0000-0002-6205-3744)
- Gabrielle Dituri
- C. J. Bui
- Joe Iwanaga
- Joseph Lockwood (ORCID: https://orcid.org/0000-0002-5289-7011)
- R. Shane Tubbs (ORCID: https://orcid.org/0000-0003-1317-1047)
- Nicolás E. Ottone (ORCID: https://orcid.org/0000-0002-3056-9703)
Institutions
- Tulane University (US)
- Universidad de La Frontera (CL)
- Ochsner Health System (US)
- Kyushu University (JP)
- University of Novi Sad (RS)
- Kurume University Medical Center (JP)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti Ospitalieri di Cremona (IT)
- Azienda Socio Sanitaria Territoriale di Cremona
Publication Details
- Journal
- Anatomy & Cell Biology
- Published
- 2026-05-08
- DOI
- https://doi.org/10.5115/acb.25.347
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00