Dual-Modal Serum and Urine SERS Metabolic Fingerprint for the Diagnosis and Activity Assessment of Childhood Lupus Nephritis
= 60). The dual-modal fusion model demonstrated superior performance over single-modal models in both LN diagnosis and disease activity assessment, achieving notably enhanced sensitivity, specificity, and overall accuracy. Furthermore, dual-modal SERS profiling revealed key biomolecular alterations associated with immune activation, inflammatory responses, and renal injury in children, providing molecular-level insights into the pathophysiological mechanisms underlying cSLE and LN.
Authors
- 范列英
- Jianmin Sang
- Xuewei Ding (ORCID: https://orcid.org/0000-0002-6215-9581)
- Qianying Lv (ORCID: https://orcid.org/0000-0003-0262-571X)
- Jiangming Wang
- Ming Zong (ORCID: https://orcid.org/0000-0003-4948-0036)
- L K He
- Jiayi Yuan (ORCID: https://orcid.org/0009-0001-1526-1495)
- Xu Sun
- Shibo Cao
- Zicheng Yang
- Xiaoyu Zha
- Lu Qu
Institutions
- Tongji University (CN)
- Shanghai East Hospital (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.analchem.6c00198
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China