Cocrystal mitigates the effects of elevated gastric pH on oral absorption of weakly basic drugs: a case study with ketoconazole-succinic acid cocrystal on beagle dogs
(7.5 times). These findings demonstrate that cocrystals of weakly basic BCS-class II drugs with acidic coformers promise to improve therapeutic outcomes that are otherwise limited by disease states or co-administration of drugs and food that increase gastric pH.
Authors
- Tatiane Cogo Machado (ORCID: https://orcid.org/0000-0002-0182-7152)
- Duxin Sun (ORCID: https://orcid.org/0000-0002-6406-2126)
- Naír Rodríguez-Hornedo (ORCID: https://orcid.org/0000-0002-2849-1986)
- Yitian Marguerite Tucci
Institutions
- University of Technology Sydney (AU)
- University of Michigan (US)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.ejps.2026.107550
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences