Protocatechuic Acid Ethyl Ester Protects Against Doxorubicin-induced Cardiotoxicity in Rats

Background: Doxorubicin, an anti-neoplastic agent, is linked with a risk of cardiotoxicity following acute or cumulative doses. Protocatechuic acid ethyl ester, as a natural phenolic acid derivative, inhibits a prolyl hydroxylase enzyme with iron-chelating and antioxidative properties. This study evaluated the effects of protocatechuic acid ethyl ester on cardiotoxicity induced by doxorubicin in an animal model. Methods: day. Recording of the electrocardiogram, assessment of serum parameters of aspartate aminotransferase, lactate dehydrogenase, creatine phosphokinase-MB, malondialdehyde and total antioxidant capacity as ferric reducing antioxidant power, and histopathological inspection of heart tissues were performed. Results: <0.05). Conclusions: Findings of this study indicated that protocatechuic acid ethyl ester has noteworthy potential to mitigate the cardiotoxicity associated with doxorubicin, possibly through alleviating oxidative stress.