Searching for <scp>LADA</scp> in patients with Hashimoto's thyroiditis: A tool for the prevention of <scp>LADA</scp>

Autoimmune thyroid diseases (AITD), such as Hashimoto's thyroiditis (HT), frequently co-occur with autoimmune diabetes, including latent autoimmune diabetes in adults (LADA). While guidelines recommend thyroid autoantibody screening in patients with autoimmune diabetes, the reverse approach-screening for diabetes-related autoantibodies in AITD patients-is not routinely practiced. Given the substantial link between glutamic acid decarboxylase antibodies (GADA) and both thyroid and β-cell autoimmunity, we recommend frequent GADA testing in AITD patients, especially those with HT. This screening technique may discover LADA early, leading to timely glycaemic monitoring and treatment measures to protect β-cell function and reduce diabetes complications.

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Publication Details

Journal
Journal of Diabetes Investigation
Published
2026-05-08
DOI
https://doi.org/10.1111/jdi.70318
Primary Topic
Diabetes and associated disorders
Type
article
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article

Searching for LADA in patients with Hashimoto's thyroiditis: A tool for the prevention of LADA

Pozzilli Paolo, Kozlowska Alicja Anna, Messina Maria Vittoria
Journal of Diabetes Investigation
Diabetes and associated disorders
article

Searching for LADA in patients with Hashimoto's thyroiditis: A tool for the prevention of LADA

Pozzilli Paolo, Kozlowska Alicja Anna, Messina Maria Vittoria
article en

Abstract

Autoimmune thyroid diseases (AITD), such as Hashimoto's thyroiditis (HT), frequently co-occur with autoimmune diabetes, including latent autoimmune diabetes in adults (LADA). While guidelines recommend thyroid autoantibody screening in patients with autoimmune diabetes, the reverse approach-screening for diabetes-related autoantibodies in AITD patients-is not routinely practiced. Given the substantial link between glutamic acid decarboxylase antibodies (GADA) and both thyroid and β-cell autoimmunity, we recommend frequent GADA testing in AITD patients, especially those with HT. This screening technique may discover LADA early, leading to timely glycaemic monitoring and treatment measures to protect β-cell function and reduce diabetes complications.

Journal of Diabetes Investigation
St Bartholomew's Hospital (GB), Università Campus Bio-Medico (IT)
Good health and well-being
Openalex Percentile: Top 6%
Diabetes and associated disorders
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