AOP-Guided Toxicogenomic Mapping Profiles for Mechanism-Informed Toxicity Pattern Prediction in Zebrafish
experiments. The individual-level effects predicted through AOP-CTMP showed strong consistency with actual observed toxicity patterns, confirming the reliability and practical potential of this approach. The results underscore that AOP-CTMP, enabling prediction of toxicity patterns from chemical perturbations, offers a novel and systematic strategy for key effects identification during toxicity screening.
Authors
- Xiangtian Meng (ORCID: https://orcid.org/0000-0001-5153-1352)
- Haoyue Tan (ORCID: https://orcid.org/0000-0003-1217-4588)
- 胡冠九
- Tianle Fan
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Beibei Zhang (ORCID: https://orcid.org/0009-0009-6889-3291)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Hongxia Yu (ORCID: https://orcid.org/0000-0001-9052-4999)
- Wei Shi
- Wenqi Xu
- Jing Guo (ORCID: https://orcid.org/0009-0008-7992-122X)
- Aoran Gu
- Qian Cui
- Changsheng Qu (ORCID: https://orcid.org/0000-0003-4987-1045)
Institutions
- Yunnan University (CN)
- Ministry of Ecology and Environment (CN)
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Environmental Protection Engineering (Greece) (GR)
- Guangdong Province Environmental Monitoring Center (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Environmental Science & Technology
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.est.6c01532
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Natural Science Foundation of Jiangsu Province
- Jiangsu Provincial Key Research and Development Program
- National Key Research and Development Program of China