Prenylated Isoflavones Originating from East African Medicinal Plants Selectively Modulate the α-Glucosidase from <i>Saccharomyces cerevisiae</i>
α-glucosidase by 53.7 ± 8.8% and 41.5 ± 8.2%, respectively. To the best of our knowledge, these are the first examples of small molecule activators of this enzyme.
Authors
- Julia Greese
- Bernd Schmidt (ORCID: https://orcid.org/0000-0002-0224-6069)
- Kai Lüersen (ORCID: https://orcid.org/0000-0001-5812-1196)
- Eric Sperlich (ORCID: https://orcid.org/0000-0002-3118-9518)
- Alexandra Kelling
- Gerald Rimbach
- Taye B. Demissie
- Vaderament-Alexe Nchiozem-Ngnitedem (ORCID: https://orcid.org/0000-0001-8337-9260)
- Friederike Neuber
- Sarah von Chamier-Gliszczinski
Institutions
- University of Botswana (BW)
- University of Potsdam (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00411
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutscher Akademischer Austauschdienst
- Universität Potsdam
- Organisation for the Prohibition of Chemical Weapons