Variants at 8p21.3 Mediate <scp> <i>BMP1</i> </scp> Expression, Contributing to Higher Atopic Dermatitis Risk
Summary Box 8p21.3 polymorphisms associate with lower BMP1 expression, lower skin hydration and increased AD susceptibility. Regulatory variants at 8p21.3 reduce BMP1 promoter activity in dermal fibroblasts, mediating its downregulation.
Authors
- Kavita Reginald (ORCID: https://orcid.org/0000-0003-1530-5934)
- Fook Tim Chew (ORCID: https://orcid.org/0000-0003-1337-5146)
- Yang Yie Sio (ORCID: https://orcid.org/0000-0002-3549-1706)
- Jia Yi Karen Wong (ORCID: https://orcid.org/0009-0006-2800-4451)
- Yi Ying Eliza Lim (ORCID: https://orcid.org/0000-0002-7116-8172)
- Yee‐How Say (ORCID: https://orcid.org/0000-0003-2363-5239)
Institutions
- National University of Singapore (SG)
- Sunway University (MY)
- Universiti Tunku Abdul Rahman (MY)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1111/cea.70332
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Singapore Food Agency
- Agency for Science, Technology and Research
- National University of Singapore
- National Research Foundation Singapore
- Economic Development Board - Singapore
- Ministry of Education - Singapore
- Sunway University
- Singapore Immunology Network