Outside Front Cover: A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase
The enzyme UDP-galactose-4-epimerase (GalE) is crucial for the cellular biosynthesis of nucleotide-sugars. In the Research Article e20304, Benjamin Schumann and co-workers use a synergistic fragment screening strategy to develop both covalent and non-covalent inhibitors against GalE. The work is underpinned by high-resolution crystallography of enzyme-inhibitor complexes. Image by Dr Stephane Mouilleron.
Authors
- Stéphane Mouilleron (ORCID: https://orcid.org/0000-0001-7977-6298)
- Ganka Bineva‐Todd (ORCID: https://orcid.org/0000-0001-8926-9417)
- Chloë Roustan (ORCID: https://orcid.org/0000-0002-8439-8997)
- Jacob T. Bush (ORCID: https://orcid.org/0000-0001-7165-0092)
- Alfred E. Doherty
- William M. Browne (ORCID: https://orcid.org/0000-0003-2647-3714)
- Francesca Zappacosta (ORCID: https://orcid.org/0009-0006-7925-2332)
- Jonathan Pettinger (ORCID: https://orcid.org/0000-0002-8219-8369)
- Christelle Soudy (ORCID: https://orcid.org/0000-0003-2603-309X)
- Benjamin Schumann (ORCID: https://orcid.org/0000-0001-5504-0147)
- Simone Kunzelmann
- Svend Kjær (ORCID: https://orcid.org/0000-0001-9767-8683)
- Saskia Pieters
- Teresa Weckwerth
- Sing Hei Lok
- Louisa Penicaut
- Raveena Prema
- Roksana Ogrodowicz
- Andrew Purkiss
- Isobel Oram
- David House
- Joanna Redmond
- Robert Quinlan
Institutions
- University of Strathclyde (GB)
- Age UK (GB)
- The Francis Crick Institute (GB)
- South College (US)
- Hochschule für Technik und Wirtschaft Dresden – University of Applied Sciences (DE)
- Imperial College London (GB)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1002/anie.2026-m0405080100
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00