Cubic Millimeter High Resolution <scp>3D</scp> Inner‐Volume <scp>GRASE</scp> ( <scp>IV</scp> ‐ <scp>GRASE</scp> ) <scp>CEST MRI</scp> Using <scp> T <sub>1</sub> </scp> ‐Integrated Variable Density <scp>CAIPI</scp> Sampling With Temporal Random Walk:
PURPOSE: To develop a cubic-millimeter, high-resolution CEST MRI sequence with enhanced efficiency and quantitative stability. METHODS: and CEST datasets. Feasibility was evaluated in phantoms and preliminary patient studies. RESULTS: and Z-spectral measurements with inherently co-registered datasets. Preliminary patient imaging revealed heterogeneity within the diseased region and exchange-dependent relaxation contrast, clearly differentiating it from contralateral normal tissue. CONCLUSION: -CEST MRI sequence provides efficient, artifact-reduced, and quantitatively reliable high-resolution imaging in a single acquisition, advancing the feasibility of quantitative CEST analysis.
Authors
- Hahnsung Kim (ORCID: https://orcid.org/0000-0002-0799-6985)
- Phillip Zhe Sun (ORCID: https://orcid.org/0000-0003-4872-1192)
- Ranliang Hu (ORCID: https://orcid.org/0000-0001-7767-1652)
- Jinsuh Kim (ORCID: https://orcid.org/0000-0002-4252-0229)
- Julius Juhyun Chung (ORCID: https://orcid.org/0000-0002-1513-5181)
- Suhyung Park (ORCID: https://orcid.org/0000-0002-7499-9377)
- Kimberly B. Hoang (ORCID: https://orcid.org/0000-0003-3796-4949)
- David A. Feinberg
- Jeffrey Olson
Institutions
- Chonnam National University (KR)
- Emory University (US)
- Advanced MRI Technologies (United States) (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1002/mrm.70397
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Advancing Translational Sciences