Development and Characterization of <i>N</i> -Acetylcysteine-Conjugated PAMAM Dendrimers: Biophysical Evaluation of Their Interactions with Proteins and Drug Delivery Applications
pharmacokinetic profile of paclitaxel-loaded NG4.0 demonstrated the sustained and elevated levels of drugs for an extended period following NAC conjugation. Our findings clearly show the efficacy of the NAC-functionalized PAMAM dendrimer, which is biocompatible and could efficiently carry and internalize payloads to glioma cells. Therefore, the paclitaxel-loaded dendrimeric conjugates may serve as a promising chemotherapeutic formulation, exhibiting better efficacy and lower toxicity.
Authors
- Keerti Jain (ORCID: https://orcid.org/0000-0002-4121-4596)
- Anchal Pathak (ORCID: https://orcid.org/0000-0001-7842-4194)
- Mukesh Nandave (ORCID: https://orcid.org/0000-0002-6535-6505)
- Gijith Mohan K M
Institutions
- Delhi Pharmaceutical Science and Research University (IN)
- National Institute of Pharmaceutical Education and Research (IN)
- CIBBIM-Nanomedicine (ES)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acsabm.6c00166
- Primary Topic
- Dendrimers and Hyperbranched Polymers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Council of Medical Research