Nickel-Catalyzed Carbonylative Synthesis of β-Ketonitriles from α-Bromonitriles and Arylboronic Acids
A new carbonylation reaction of α-bromonitriles with arylboronic acids has been explored for the synthesis of β-ketonitriles. Notably, the reaction is catalyzed by an inexpensive nickel catalyst and operates under mild reaction conditions without the direct use of gaseous CO. It demonstrates a general and complementary carbonylation route for the synthesis of valuable β-ketonitrile products, and a variety of products were obtained in moderate to high yields with good functional group tolerance. Moreover, the synthetic utility of this method is evidenced by a scale-up experiment and subsequent functionalization of the resulting β-ketonitriles.
Authors
- Jiacong Ma
- Zilin Huang (ORCID: https://orcid.org/0009-0003-7369-2917)
- Yuting Jiang (ORCID: https://orcid.org/0000-0002-0400-6042)
- Xinxin Qi
- Xiao-Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
Institutions
- Zhejiang Sci-Tech University (CN)
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Leibniz Institute for Catalysis (DE)
- Ingenierie des Materiaux polymeres (FR)
- Dalian National Laboratory for Clean Energy (CN)
- Interface (United Kingdom) (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.orglett.6c01685
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China