Synthesis of 2-Acylpyrroles and 5,6-Dihydro-4 <i>H</i> -furo[3,4- <i>c</i> ]pyrrol-4-ones via Silver/Base Promoted Intramolecular Hydroalkylation and Oxidation of Propargylamines
]pyrrol-4-ones through silver/base promoted tandem reactions of intramolecular hydroalkylation and oxidation of propargylamines has been developed successfully. The strategy has the advantages of one-pot synthesis, easily available raw materials, good atomic economy, wide functional group tolerance, and excellent regioselectivity. Moreover, this method can also be used to construct 2-acylfuran, further expanding its applicability.
Authors
- Niannian Yi (ORCID: https://orcid.org/0000-0001-6008-5649)
- Rong Yang (ORCID: https://orcid.org/0009-0006-5747-8963)
- Zhiwen Zhou (ORCID: https://orcid.org/0000-0001-7447-0185)
- Bing Yi (ORCID: https://orcid.org/0000-0003-2869-0691)
- Ziyan Li
- Jie Li
- Yi Xiong
- Xingyi Chen
- Peishan Wu
Institutions
- Hong Kong Baptist University (HK)
- Hunan Institute of Engineering (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.joc.6c00552
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China