Sex-Specific Modulation of Drug Metabolizing Enzymes, Transporters, and Pro-Inflammatory Cytokines by Arsenic Trioxide in C57Bl/6 Mice
elevation. Collectively, these findings highlight sex-dependent modulation of hepatic ATO handling and drug metabolizing capacity, with important implications for risk assessment and individualized ATO containing regimens.
Authors
- Sara R. El-Mahrouk
- Ayman O.S. El‐Kadi (ORCID: https://orcid.org/0000-0002-8692-0400)
Institutions
- University of Alberta (CA)
- Tanta University (EG)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- Chemical Research in Toxicology
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.chemrestox.6c00114
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Society
- Leukemia and Lymphoma Society of Canada
- Alberta Innovates
- Natural Sciences and Engineering Research Council of Canada